WHO Published Medical Advice that Cast Doubts on Gilead’s Remdesivir

Last Friday, the WHO published in The British Medical Journal an advice to doctors, which repudiates the US FDA’s approval of remdesivir as COVID-19 treatment.

Gilead, the American biotechnology company that developed remdesivir, which it manufactures under the brand name Veklury, immediately published a statement opposing the medical advice published by the World Health Organization (WHO).

The biotech company insists that remdesivir is regarded as a customary treatment in aiding patients battle against the coronavirus disease. Gilead cited guidelines from various reliable organizations worldwide as confirmations; including those published by the Health and Infectious Diseases Societies of America, Germany, Japan and the UK.

Why is WHO Against the Use of Remdesivir as COVID-19 Treatment?

According to a panel of specialists comprising the WHO Guideline Development Group (GDG), currently, there is still not sufficient proof that the remdesivir drug is capable of increasing the survival chances of patients infected with COVIS-19, and much less, capable of speeding up recovery time. The WHO’s statement created a huge disparity between the two country’s regulatory guidance on the acceptability of medications used as coronavirus treatments.

The panel of specialists are experts coming from all around the globe, who based their recent findings on comparisons made over the different effects yielded by various COVID-19 drug treatments. Additionally, the panel of international experts also provided evidence from four random international clinical trials that encompass over 7,000 hospitalized patients infected by the virus.

With the data they have collected, the expert panel of WHO GDG concluded that the antiviral drug remdesivir has no effect as far as reducing the mortality of the patients are concerned. Additionally the GDG also discovered that remdesivir has no meaningful significance in determining a patient’s need for mechanical ventilation or in determining the period for clinical improvement.

About FDA’s Approval in the Use of Remdesivir as Coronavirus Treatment

A month ago, the US Food and Drug Administration approved the use of the Veklury antiviral drug, the branded name of the generic remdesivir medication for the treatment of Covid-19 infected adults and children over the age of 12 who weigh at least 40 kilograms or 88 pounds. Actually, the Veklury is the very first coronavirus treatment that received approval from the US FDA, but was given under a condition that the drug can only be used by healthcare facilities or hospitals that are capable of giving acute care to COVID-19 patients

As it turned out, the US FDA’s approval of the remdesivir is not applicable to the overall population as its initial approval was made under the conditions of Emergency Use Authorization (EUA). The approval was later revised in order to continuously give access to children covered by the EUA.

The administration modified the authorization of remdesivir use by including patients below 12 years old but only if the child weighs at least 3.5 to 40 kilograms. Apparently, the approval of remdesivir as a coronavirus treatment under the Emergency Use Authorization (EUA) still requires continuation of ongoing clinical trials in order to evaluate the safety and efficiency levels of the drug, particularly for the pediatric population.

Yoga for Health

There are most likely as many approaches to the physical practice of yoga as there are presents, or maybe even as many as there are those practicing it. Every yogi finds particular practices that are appealing to them, poses and fashions that resonate together and become comfortable. Now there are different tools for yoga, like yoga wheels [ chirp wheel chiropractor review ] and yoga trapezes.

But it is of crucial importance to continue to introduce new thoughts, presents, and influences in order to maintain bringing new perspective and vitality to your practice.

I do this by constantly reminding myself that there is always more to learn. Simply because I practice a tolerably great Wheel present, doesn’t signify I bypass the content from Yoga Journal that describes appropriate type for the pose. There is a really good probability that there’s an idea in that article that hasn’t occurred to me, that may allow me to go deeper into the posture, better balance the muscles, or sense it differently. I’d even find that although I have been organizing my limbs to the present for decades, I’ve been missing a crucial activity or connection which may enrich my practice of the pose.

Finding inspiration is often as simple as trying a new yoga class or instructor, to appreciate a change in pace, a different sequencing of stream or some variation on a familiar posture. If you are traveling, find a yoga class in town you’re visiting. Maybe you’ll enjoy hearing yoga instructed at a different accent or maybe you are going to be introduced to a kind of yoga which is not taught in your home town.

I like to attend workshops from instructors that traveling regionally, nationally or internationally. These educators might be yoga masters or have studied under masters of new yoga fashions or ancient Indian traditions. There’s frequently a depth of yogic knowledge and understanding that these educators use to shine fresh light on the tradition of yoga. At times it’s the fresh explanation of a theory that you’ve heard before that can help you to feel “Aha!” Time of broadening your practice and understanding.

Another excellent way to access successful teachers, such as Shiva Rea or even Baron Baptiste, is through DVDs or movies accessible on-line. It’s an opportunity to shake up your practice and attempt something fresh at the comfort of your own home. With a video, you can view more than once in case you don’t get anything the first time.

There’s so much information out there now about yoga, whether its live instruction, videos, even television and books. There are lots of opportunities to reinvigorate your love of biking and also provide a breath of fresh air to your practice that might become rancid.

The Importance of Wearing Motorcycle Gloves

Is it Really Necessary to Wear Gloves When Riding a Motorcycle?

Gloves have always been important as helmet when riding or driving a motorcycle, although there are various debates on whether gloves really promote safety because there were accident before wherein the identified cause is inappropriate gloves. But I believe that it still depends on the type of glove. As long as it it will absorb enough vibration and is anti slippery then I find it essential to wear. If you are going for a long drive, these motorcycle gloves are great for long drive. They are actually very affordable but in good quality.

If you are the type of person who is not fond of wearing gloves, then this article is for you. I listed down below reasons why I find gloves useful.

1. Makes me comfortable

Number one reason why gloves are developed is because it provides comfort to the driver. As what I have mentioned earlier, high quality motorcycle gloves do an amazing job of absorbing vibration produced by the motorcycle. Moreover, if you keep on experiencing feeling numb it will be probably better if you start looking for the best motorcycle gloves. Gloves also keep your hand from drying especially when on a long drive.

2. Gloves Promote Safety

Another reason why many drivers wear gloves is because it helps them get a great grip of  the handle. Since handlebars tend to be slippery, it may cause accident. Hence, motorcycle gloves are designed to address that problem. Mentioned in the first reason is how drivers feel numb especially after a long drive, this may not only be uncomfortable, but it can be a health hazard. You should not feel numb in order to feel the motorcycle while driving. Otherwise, it may lead to negative impact.

3. Additional style 

Aside from the comfort and safety provided by the gloves, style is just a bonus. There are various styles available for men, women, child, and adult.

4. Protection

Gloves also add protection. When we fall on the ground the first this we will most likely do is to use our hands. Gloves give protection to hands from wounds.

A Study Says Curbing Sebum May Help Lessen Acne

Acne is the cause of the misery of a lot of teens as well as several adults. This leads to many of them seeking for acne treatment and other skincare products and routines in the hopes of getting rid of and prevent acne.

A team of researchers discloses that they may have arrived at a new method to alleviating the said condition. The solution lies in skin oil, known as sebum, which is naturally produced. This research was conducted by a team headed by William Esler, a researcher at Pfizer in Cambridge, Massachusetts.

Curbing Sebum May Help Lessen Acne

Sebum is essential to the health of the skin since it aids to normalize temperature as well as keep microbes at bay, stated the team. However, the overproduction of sebum has as well long been believed to be one cause of acne. Excessive sebum could get blocked in glands, causing it to puff up and produce a bump underneath the skin. This was explained by Dr. Raman Madan, the dermatologist at Northwell Health’s Huntington Hospital. According to Dr. Madan, who wasn’t part of the new research, distinguishing a goal to lessen the production of sebum would be an innovative method to acne treatment.

The study encompassed a microscopic analysis of the skin of 22 hale and hearty participants who volunteered for the research. The team learned that sebum production of the skin depends on a certain molecular system called the de novo lipogenesis or DNL pathway.

The Findings

Majority of the sebum was discovered to be created by sebocytes, which produced the oil based on the DNL pathway’s ebb and flow. However, nine participants with acne displayed one main differentiation. The outcomes showed that when matched up to individuals having normal skin, they carry a 20% higher level of production of sebum as well as a related increase in fluxes of the DNL pathway.

Furthermore, as per the report printed in the May 15 issue of Science Translational Medicine, the team of Esler created a compound that aimed at an enzyme that has to do with the pathway. In volunteers who are healthy, the use of the treatment lessened the production of sebum by almost half.

Sure enough, these tests are early and it continues to be observed if such a compound may limit sebum (and acne) in a bigger, more thorough test.

In the interim, Dr. Madan mentioned that the given methodology “has potential.” However, he warned that this approach might be an acne treatment, not an acne cure since the cause of acne is beyond just the production of sebum. Moreover, he also said that it has the potential to be an add-on to existing acne treatments.

Dr. Michele Green also concurred that the discovery might offer possibilities to patients with acne vulgaris. Dr. Green is a dermatologist at Lenox Hill Hospital, New York City.

Young Mormons Rewarned about LDS Church’s Prohibition vs. Coffee, Vaping, Marijuana and Any Habit-Forming Substances

In light of Starbucks’ impending plan of opening its first outlet near Brigham Young University of the Mormon church, members of the Church of Jesus Christ of Latter-day Saints or LDS, particularly the youth, are rewarned about the faith’s prohibition against coffee and any drinks containing caffeine.

As reassertion and renewal of the LDS church’s warnings, a comprehensive set of new guidelines were published in the August edition of the Mormon youth magazine New Era; furnishing clear statements pertaining to the prohibitions mentioned in the church’s “Word of Wisdom.”

The reiteration stated that there are no gray areas when it comes to the prohibitions prescribed as Mormon health codes. The “Word of Wisdom’s” forbiddance encompasses all habit-forming substances including tea, vapes, cigarettes, marijuana, or any drink that includes caffeine, mocha, espresso, latte or -ccino in its product name.

The need to reiterate the LDS church’s prohibition is also in light of the concerns raised by a 2016 survey, which revealed that four (4) out of every ten (10) active Mormons below 51 years old, who responded to the survey, admitted to having drank coffee during the past six months from the date the survey was taken.

Some Key Points about the New LDS Guidelines Clarifying the Prohibited Substances

The new guidelines though made clarification that prohibition against marijuana is only if the substance is used for recreational purposes. The guidelines made mention that marijuana if medically prescribed and administered, is not forbidden. In addition, it specifically states that recommendation of marijuana as prescribed treatment must come from competent medical practitioners.

Moreover, the guidelines no longer include the hardline prohibition against entering coffee-shops like Starbucks, which for many years were regarded as taboo. Instead, young Mormons are given advise that when ordering a drink from an outlet, particularly if the shop specializes in coffee beverages, to always ask first if the concoction includes coffee, caffeine or tea as an ingredient.

Vapes, even if advertised as an alternative to conventional cigarettes, still contain nicotine and have been ascertained as addictive substitutes as well. The prohibition therefore includes vapes that come in fruity or other alluring flavors.

About the LDS Church’s “Word of Wisdom”

The “Word of Wisdom” refers to the book containing 1833 section of the Doctrine and Covenants considered by Mormon faith as compilation of revelations from God that LDS founder Joseph Smith received in 1833.

Strict compliance with the health codes set in the “Word of Wisdom” is a prerequisite for Mormon baptism, for rendering full-time missionary work, in attending Mormon church schools, and in entering LDS places of worship. Violation of the code though is not considered as ground for excommunication or any form of disciplinary action.

Aging and Other Stressors that Cause Degenerative Disc Diseases

2 Corinthians 4:16
“So we do not lose heart. Though our outer self is wasting away, our inner self is being renewed day by day.”

The gospel tells us there is honor in aging because the process normally increases wisdom through experiences. Yet the unsettling truth about growing old is that it is often accompanied by degeneration of the physical body. While the progression of degenerative disorders can be stalled, such conditions can prevent continued participation in normal day to day activities with the usual vim and vigor.

Let us cite as an example the degenerative disc disease, which happens as a person grows older. Actually, the condition is not a disease but is a disorder that occurs as part of the ageing process. Understand that parts of the spinal column are spinal discs lodged between vertebrae. A doctor may refer to them as intervertebral discs that function essentially as a cushion between each vertebra that makes up the spine.

What Happens When a Person Has Degenerative Disc Disease?

Whenever a person moves, the soft, gelatinous inner core of an intervertebral disc makes moving about and exerting force, as well as heaving or lifting loads less stressful on the spine.

Yet as a person goes through the years of performing different activities, the inner core of the intervertebral discs degenerates, eventually losing suppleness. As a result there will be friction between vertebrae on every spine movement, causing pain at the lumbar or base of the spine.

As the degenerative state advances when a person ages, weakness caused by numbness and pain radiating down to the thigh and leg will render that person less ambulatory. In severe cases of degenerative disc disease, the afflicted person loses his or her ability to walk about, without aid or assistance.

Aging though is not the only condition that leads to intervertebral degenerative discs. Obesity, strenuous labor, frequent physical work, tobacco smoking, or an injury, may result in disc degeneration. The resulting back pain may start as a slight discomfort that is initially manageable, but could worsen over time if stress is not alleviated and treated.

Conservative and Other Therapeutic Treatments

Conservative treatments of back pain caused by degenerative disc disorder include pain-relief medication and anti-inflammatory drugs. In special cases, the attending physician may prescribe muscle relaxers or steroids. Medical treatment may be accompanied by physical and/or occupational therapy, weight loss program or special exercises.

In severe or inexorable cases, surgery or medical options such as Lumbar Fusion, Epidural Steroid Injection, Disc Replacement Surgery or other similar advanced spinal treatment may be necessary.

Sufferers of back pain due to degenerative disc disorder residing in, or around Austin, Texas do not have to go far in seeking appropriate treatment. The Central Texas Spine Institute offers full services for spinal care, conservative treatment and surgery.

𐌢